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Physical Biology of the Cell, by Rob Phillips, Jane Kondev, Julie Theriot, Hernan Garcia
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Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that unite a given set of biological phenomena. Herein lies the central premise: that the appropriate application of a few fundamental physical models can serve as the foundation of whole bodies of quantitative biological intuition, useful across a wide range of biological problems. The Second Edition features full-color illustrations throughout, two new chapters, a significantly expanded set of end-of-chapter problems, and is available in a variety of e-book formats.
- Sales Rank: #30620 in Books
- Brand: Brand: Garland Science
- Published on: 2012-10-29
- Original language: English
- Number of items: 1
- Dimensions: 11.00" h x 10.00" w x 2.00" l, 4.60 pounds
- Binding: Paperback
- 1057 pages
- Used Book in Good Condition
Review
“The book is well illustrated, problems and references complete each chapter, figures and other data can be downloaded from the Garland Science Web site. Its public is assumed to be students taking a first course in physical biology or biophysics, and scientists interested in physical modelling in biology. Physical Biology of the Cell has much to offer to both categories…”
- Crystallography Reviews
“This textbook is an excellent resource, both for a research scientist and for a teacher. The authors do a superb job of selecting the material for each chapter and explaining the material with equations and narrative in an easily digestible manner.”―Yale Journal of Biology and Medicine (YJBM)
Praise for the First Edition of Physical Biology of the Cell
“Physical Biology of the Cell…aims to be both an introduction to molecular and cellular biology for physicists and an introduction to physics for biologists. Though that sounds like a daunting task, the book fully and impressively delivers. Physical Biology of the Cell might well become a similar classic [as Molecular Biology of the Cell] for anyone who heeds its mantra “quantitative data demand quantitative models.” It will give both physicists and biologists a useful introduction into the other camp’s methods and ways of thinking.”
―Ralf Bundschuh, Physics Today, 2009
“[The] authors of Physical Biology of the Cell have produced one of the first multi-purpose textbooks that is readily accessible to both physicists and biologists….When read from cover to cover, the book is both very instructive and highly entertaining, with the authors using humor to deliver strong take-home messages in each chapter....Physical Biology of the Cell provides instructors with excellent material to create a graduate level course in biology or physics.”
―Patricia Bassereau and Pierre Nasoy, Nature Cell Biology, 2009
“Physical Biology of the Cell is beautifully crafted: self-contained and modular, it provides tutorials on fundamentals and has material to hold the interest of a more sophisticated reader. It is fast-paced, proceeding within each chapter from freshman basics to graduate level sophistication. To truly master the physics presented in the
book, one should do the problems provided with each chapter. These problems are well thought out and are a major teaching resource.”
―Boris Shraiman, Cell, 2009
“…a monumental undertaking by three outstanding experts in the field…the book is a rich collection of special topics in biophysics…”
―Gabor Forgacs, Quarterly Review of Biology, 2009
“I would thoroughly recommend [Physical Biology of the Cell] to anyone interested in investigating or applying biophysical research methods to their work. It is likely to be a fantastic teaching tool and is a welcome addition in this age of increasingly
interdisciplinary science.”
―David Stephens, The British Society for Cell Biology Newsletter, 2009
About the Author
Rob Phillips is the Fred and Nancy Morris Professor of Biophysics and Biology at the California Institute of Technology. He received a PhD in Physics from Washington University in St. Louis.
Jane Kondev is a Professor of Physics in the Graduate Program in Quantitative Biology at Brandeis University. He received his Physics BS degree from the University of Belgrade, and his PhD from Cornell University.
Julie Theriot is a Professor of Biochemistry and of Microbiology and Immunology at the Stanford University School of Medicine. She received concurrent BS degrees in Physics and Biology from the Massachusetts Institute of Technology, and a PhD in Cell Biology from the University of California at San Francisco.
Hernan G. Garcia is an Associate Research Fellow at Princeton University. He received a BS in Physics from the University of Buenos Aires and a PhD in Physics from the California Institute of Technology.
Most helpful customer reviews
12 of 13 people found the following review helpful.
Mind opening text book!
By M-Razo
The second edition of Physical Biology of the Cell doesn't fall short to the expectations I had based on the master piece that I found in the first edition.
This book guides you in an extremely friendly way through the fascinating interface between biology and the more quantitative science. The authors present in an exquisite way how tools borrow from physics and mathematics can be used to gain deeper insight into biological problems.
With a brand new chapter and entertaining "Computational Exploration" sections, along with full colored images, the authors came again with a beautiful text book for any naive or field expert reader that decides to dive into the beauty of Physical Biology of the Cell
8 of 8 people found the following review helpful.
A textbook based on physical models of cellular mechanics and chemistry
By Ulfilas
This large, 800-page, 20 chapter, 9"x11" textbook is the size of a phonebook for a city of 200,000 people or so. Using many nicely-drawn figures and mathematical models, the authors work to unite the disciplines of biology, chemistry, and physics.
Chapters 1 and 2 begin the book by first describing the molecular structure of the chemical compounds found in the cell, and then the geometry of the cell and its components. Chapter 3 addresses the time scale and time constraints for cellular processes. The hierarchy of biological time scales is summed up by Fig.3.2 on pp.78-79. There it is seen that protein synthesis requires tens of seconds, as does RNA transcription. Gating of ion channels requires only a single second, while enzyme catalysis requires only a microsecond. The authors provide a good example of complex molecular synthesis via an experiment showing the evolving molecular components of the bacterial flagellum--the assembly of which is seen to require about 3 hours (p.104). The authors mention that the E. coli bacteria are able to divide in as little as 1000s, although copying its genome alone (i.e DNA replication) would seem to require 3000s (p.92). It is found, however, that E. coli are able to get a jump on DNA replication by starting to replicate its daughter's, granddaughter's, and great-granddaughter's chromosomes before it has even completed its own (p.113). It is also noted that the 3000s division time for E. coli division corresponds to the case where the environment supplies only glucose. For the case where the environment is rich in amino acids, the division time may be cut by a factor of two.
Beginning with chapter 5 "Mechanical and Chemical Equilibrium in the Living Cell," this book draws heavily on an understanding of statistical mechanics and thermodynamics at the level of an advanced undergraduate or graduate course or textbook on that topic (e. g. Reif's Fundamentals of Statistical and Thermal Physics). Chapter 6, entitled "Entropy Rules," dedicates itself to the development of statistical mechanics, and chapter 7 applies these concepts to two-state systems. Chapter 8 applies statistical mechanics to the folding of polymer chains via a random walk analogy, especially with regard to DNA. Chapter 9, "Electrostatics for Salty Solutions," applies the techniques learned in a sophomore-level undergraduate course on electricity and magnetism to the electrical screening of macromolecules in a saline solution (e.g. Kip's Fundamentals of Electricity and Magnetism Second Edition).
The bending and flexing of cell elements is discussed in chapters 10 and 11. Chapter 12 is dedicated to fluid flow, chapter 13 concerns diffusion, and chapter 14 deals with the influence of cell size on transport. Chapter 15 addresses cellular chemical reactions, including cytoskeletal polymerization and enzyme kinetics. Chapter 16 concerns molecular motors and chapter 17 is on membrane permeability. Chapter 18 is about evolutionary genetics and biological clocks. Chapter 19 discusses of the regulation of cell processes. Chapter 20 brings the book to a close by examining whether mathematical modes, such as those described in this volume, are able to accurately model the cell.
2 of 2 people found the following review helpful.
I liked the book!
By Nina
I used this book for an undergraduate/beginners graduate course on biophysics, and read through all of it in 4 months. It is a fairly self-contained book, with few serious gaps. Admittedly, it is not light reading, but the festive and playful attitude of the authors is very welcome. I firmly believe that both the students and I learned a lot, both of biology and of physics. For the authors: as a teacher, I would appreciate it a lot if you could have all the equations in a collection of ppt files, the same way as you have all the figures in the book.
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